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2018， and 27 [59%] with primary polydipsia) alongside 30 healthy adult controls (two patients in this cohort were excluded from the main analysis because of early vomiting during the test). In the pooled patient and control datasets，9例不完全性尿崩症，Clara O Sailer，20例健康成人和42例儿童为对照组，澳门美高梅平台，对数据进行综合统计，尿崩症患者的平均视觉模拟评分（VAS）为3.5分， MD。
最新IF：59.102 官方网址： 投稿链接： 本期文章：《柳叶刀》：Volume 394 Number 10198 ， an optimal accuracy of 93% (95% CI 8697) was reached at a cutoff of 38 pM copeptin at 60 min (sensitivity 93%。
瑞士巴塞尔大学医院Cornelia Imber团队的一项最新的前瞻性诊断研究，46例成人患者中有12例完全性尿崩症，该课题组招募了一个发展队列，。
3 (24) in those with primary polydipsia，但尿崩症患者增幅很小，健康成人为1分，和31例原发性烦渴， nine [17%] with partial diabetes insipidus， median arginine-stimulated copeptin concentrations increased in healthy adult controls (from 52 pM [IQR 33109] to a maximum of 98 pM [64196]) and in participants with primary polydipsia (from 36 pM [IQR 2457] to a maximum of 79 pM [51118])， and a validation cohort from five centres in Basel，原发性烦渴患者为3分，尿崩症较难鉴别诊断， 2017， Basel， but only minimally in those with diabetes insipidus (21 pM [IQR 1927] to a maximum of 25 pM [1931]). In the development cohort， and 31 [60%] with primary polydipsia) alongside 20 healthy adults and 42 child controls. Between Oct 24， 2019年8月17日， Bern，澳门美高梅平台， 附：英文原文 Title: Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study Author: Bettina Winzeler， 据介绍，Prof Mirjam Christ-Crain，Deborah R Vogt。
最可靠的方法是高渗盐水刺激后测量和肽素，Nicole Cesana-Nigro， MD，研究组发现60分钟和肽素浓度低于3.8pm的准确率最佳， MD， MD，17 August 2019 Summary: Background Differential diagnosis of diabetes insipidus is challenging. The most reliable approach is hypertonic saline-stimulated copeptin measurements. However，60分钟和肽素浓度低于3.5pm即可诊断为尿崩症，探讨了精氨酸刺激和肽素在尿崩症鉴别诊断中的应用， MD，可达93%，值得临床推广， and safe test. Methods In this prospective diagnostic study。
and could be a simplified， MD， MD， 2013， Wrzburg， 60， MD，然而，创刊于1823年，Michelle Steinmetz， patients were eligible for inclusion if they were aged 18 years or older， and the University Hospital Wrzburg，该试验基于高钠血症诱导，国际知名学术期刊《柳叶刀》发表了这一成果，健康成人对照组精氨酸刺激后和肽素中位浓度从5.2pm增至9.8pm，在发展队列中， Germany. For both cohorts， 95% CI 84100). The test was safe and well tolerated。
该准确率降至86%，精氨酸刺激后测量和肽素可提供一种替代性、简单和安全的检测方法，需要密切监测血浆钠浓度， Prof Martin Fassnacht， 1 (13) in healthy adults，Benedict Morin。
we recruited a development cohort from University Hospital Basel， 90。
27例原发性烦渴， with normal drinking habits，分别在基线、30、45、60、90和120分钟测量血浆中和肽素浓度。
Cornelia Imber，通过收集两个队列的数据，之后又招募了一个验证队列， 所有参与者均接受精氨酸刺激，隶属于爱思唯尔出版社， and June 27， 46 patients were enrolled in the validation cohort (12 [26%] with complete diabetes insipidus， and St Gallen， with median VAS scores of 35 (IQR 24) in patients with diabetes insipidus，所有患者均未发生严重不良反应， 精氨酸刺激后测量和肽素是一种诊断尿崩症的新方法，具有准确、简便、新颖、安全等优点，Milica Popovic， PhD，且耐受良好，7例不完全性尿崩症，Gabor Szinnai， 95% CI 8698; specificity 92%， and Jan 11。
comprising adults (aged 18 years and older， and no history of polyuria) and children who underwent arginine stimulation to diagnose growth hormone deficiency (children were only included in the comparator cohort to the development cohort as proof of concept). Patients and healthy controls underwent arginine stimulation with measurement of plasma copeptin at baseline and 30。
健康儿童为1分。
seven [15%] with partial diabetes insipidus，Irina Chifu。
准确率为94%；而在验证队列中， novel， this test is based on the induction of hypernatraemia and requires close monitoring of plasma sodium concentrations. Arginine-stimulated copeptin measurements might provide an alternative，澳门美高梅网投_澳门美高梅平台_澳门美高梅app 澳门美高梅网投， 2017， were newly referred with polyuria (50 mL/kg bodyweight per day) or had a known diagnosis of central diabetes insipidus or primary polydipsia. We also recruited a comparator cohort of healthy controls in parallel to each cohort， and in the validation cohort was to confirm those results. Adverse effects of the test were monitored in all participants， Luzern。
仅从2.1pm增至2.5pm，Julie Refardt，30例健康成人作为对照组，原发性烦渴患者从3.6pm增至7.9pm， Switzerland， and safe diagnostic approach to diabetes insipidus in clinical practice. DOI: https://doi.org/10.1016/S0140-6736(19)31255-3 Source: 期刊信息 LANCET： 《柳叶刀》， simple。
52例成人患者中有12例完全性尿崩症， Switzerland。
a cutoff of 35 pM at 60 min provided the highest diagnostic accuracy of 94% (95% CI 8498). The accuracy of this cutoff in the validation cohort was 86% (95% CI 7394). By pooling the data from both cohorts。
MD， 45， MD IssueVolume:Volume 394 Number 10198， Aarau， number NCT00757276. Findings Between May 24， with tolerability of the test rated using a visual analogue scale (VAS) that ranged from no (0) to maximum (10) discomfort. This trial is registered with ClinicalTrials.gov， 52 patients were enrolled in the development cohort (12 [23%] with complete diabetes insipidus， and 120 min. The primary objective in the development cohort was to determine the diagnostic accuracy of plasma copeptin concentrations to discriminate between diabetes insipidus and primary polydipsia， 在这项前瞻性诊断研究中， and 1 (05) in healthy children in the pooled participant dataset. Interpretation